Immunoglobulin G2 antibodies promote neutrophil killing of Actinobacillus actinomycetemcomitans
نویسندگان
چکیده
منابع مشابه
Opsonization of Actinobacillus actinomycetemcomitans by immunoglobulin G antibodies to the O polysaccharide of lipopolysaccharide.
Sera of localized juvenile periodontitis (LJP) patients colonized by Actinobacillus actinomycetemcomitans serotype b often contain markedly elevated levels of immunoglobulin G (IgG) antibodies to serospecific determinants in the O polysaccharide of lipopolysaccharide (LPS), as well as to outer membrane proteins of this species. IgG antibodies in LJP sera are known to opsonize A. actinomycetemco...
متن کاملLytic effects of Actinobacillus actinomycetemcomitans leukotoxin on human neutrophil cytoplasts.
Actinobacillus actinomycetemcomitans leukotoxin lysed human neutrophil cytoplasts. The reaction was associated with a rapid influx of extracellular calcium, a collapse in membrane potential, release of lactate dehydrogenase, and overt disintegration of the plasma membrane. These functional and structural alterations in the plasmalemma of neutrophil cytoplasts reinforce the hypothesis that A. ac...
متن کامل[Analysis of antigens of Actinobacillus actinomycetemcomitans with monoclonal antibodies].
The purpose of this study was to analyze antigens of Actinobacillus actinomycetemcomitans. Fifteen hybridomas producing monoclonal antibodies (MAbs) against A. actinomycetemcomitans strain Y4 were obtained. These hybridomas were divided into three groups (Group 1, Group 2 and Group 3) on their MAbs' specificity. The MAbs (MAb S1-S8) produced by Group 1 hybridomas reacted with serotype b-specifi...
متن کاملEndocarditis caused by Actinobacillus actinomycetemcomitans.
Actinobacillus actinomycetemcomitans is a gram-negative coccobacillus which is a very rare cause of bacterial endocarditis. Preexisting cardiac lesions are a main contributing factor, and antibiotic prophylaxis has long been felt necessary before dental or other manipulation to prevent endocarditis. Penicillin in combination with an aminoglycoside has been the most often used treatment regimen....
متن کاملCharacterization of serologically nontypeable Actinobacillus actinomycetemcomitans isolates.
Our previous studies have shown that Actinobacillus actinomycetemcomitans isolates of a given arbitrarily primed PCR (AP-PCR) genotype belong to the same serotype (of serotypes a through e). In the present study we investigated whether the AP-PCR genotypes of nonserotypeable A. actinomycetemcomitans isolates match those of the serotypeable isolates. The isolates were additionally characterized ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1995
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.63.3.1070-1075.1995